منابع مشابه
TGF-Β1 Transduced Mesenchymal Stem Cells Have Profound Modulatory Effects on DCs and T Cells
Background: Mesenchymal stem cells (MSCs) and transforming growth factor-β1 (TGF-β1) molecules are well known for their immunomodulatory properties and their function in tissue regeneration and remodeling. Objectives: To evaluate the interaction of TGF-β1 engineered MSCs with T cells and dendritic cells (DCs) and their modulatory effect on the immune response. Methods: MSCs and DCs were generat...
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Conventional cytotoxic T lymphocytes (CTLs) that express the CD8 co-receptor alongside their clonally distributed receptor for antigen are superbly equipped to eliminate virus-infected cells. They recognize short peptide fragments of intracellular pathogens which are brought to the surface of the infected cell in the groove of the major histocompatibility complex (MHC)-encoded class I molecules...
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Little is known about the potential role of T cells in the inflammatory renal disease glomerulonephritis (GN). GN has been historically viewed as a product of immune complex-mediated complement activation, and the presence of autoantibodies made identifying T cell-specific effector contributions difficult to elucidate. In this issue of the JCI, Heymann et al. generate what they believe to be a ...
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We have previously reported that stressed apoptotic tumor cells are more immunogenic in vivo than nonstressed ones. Using confocal microscopy we have confirmed our previous observation that heat-stressed apoptotic 12B1-D1 leukemia cells (BCR-ABL(+)) express HSP60 and HSP72 on their surface. To explore how the immune system distinguishes stressed from nonstressed apoptotic tumor cells, we analyz...
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ژورنال
عنوان ژورنال: Nature Reviews Immunology
سال: 2015
ISSN: 1474-1733,1474-1741
DOI: 10.1038/nri3885